Diabetes mellitus has been considered as one of the major health concerns all around the world today. Experimental animal model are one of the best strategies for the understanding of pathophysiology of any disease in order to design and develop the drug for its treatment. Numerous animal models have been developed for the past few decades for studying diabetes mellitus and testing antidiabetic agents that induce chemical, surgical and genetic manipulations (Noor et al., 2008). One of the most potent methods to induce experimental diabetes mellitus is chemical induction by alloxan. It’s a urea derivative which causes selective necrosis of the beta cells of the pancreatic islets. In addition, it has been widely used to produce experimental diabetes in animals such as rabbit, rat, mice and dogs with different grades of diseases severally by varying the dose of alloxan used. As it has been widely accepted, alloxan selectively destroys the insulin-producing beta – cells found in the pancreas, hence it is used to induce diabetes in laboratory animals (Walter, 2007). In recent times, there has been growing interest in exploiting the biological activities of different ayurvedic medicinal herbs due to their natural origin, cost effectives and lesser side effects (H. Mohan, et al., 2005). Plants produce vast array of secondary metabolites as defense against environmental stress or other factors like pest attacks, wounds and injuries. The complex secondary metabolites produced by plants have found various therapeutic uses in medicine (Senthikumar and A. Padhiari, 2006).
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