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The study was designed to investigate the effects of administration of Aloe vera gel extract on liver enzmes on Albino rats. Twenty four male Albino rats weighing 180-200 were divided into four groups of six rats per group were used in the study. Group I which served as the control received rat food and water while those in groups II, III and IV received Aloe vera gel (100, 200 and 300mg/kg), respectively, for three weeks. The animals were sacrificed, and serum enzymes were measured using standard methods. Serum ALT concentration was nonsignificantly reduced (P>0.05) in group 2 (47.80±7.33 IU/L), compared with group 1 (54.50±3.89 IU/L), while in group 3 (63.50±3.78 IU/L) and 4 (71.17±2.40 IU/L) it was significantly increased (P<0.05) when compared with group 1. Serum ALT concentration was significantly higher (P<0.05) in group 3 compared with group 2. It was also significantly higher in group 4 compared with group 3. Serum AST concentration was nonsignificantly lower (P<0.05) in group 2 (54.17±4.40 IU/L) when compared with control (56.67±3.08 IU/L). Serum AST concentration was significantly higher (P<0.05) in group 3 (67.67±3.20 IU/L) and 4 (75.50±2.35 IU/L) when compared with control (Group 1). It was also significantly (P<0.05) higher in group 3 compared with group 1, and group 4 compared with group 3. Serum ALP concentration was nonsignificantly lower (P>0.05) in group 2, 3 and 4 (77.17±4.02 IU/L, 75.17±5.71 IU/L and 73.67±4.63 IU/L respectively) when compared with control (81.67±4.84 IU/L). Serum ALP concentration was nonsignificantly lower (P>0.05) in group 3 when compared with group 2, and in group 4 when compared with group 3. In conclusion, Alovera gel has hepatoprotective and hepatotoxic effect.