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The importance of health to economic growth of any economy cannot be overemphasized, to this effect this study examined the impact of Health Expenditure and Health Outcome in Nigeria Economic Growth from 1980 to 2015.The study made use of secondary data sourced from the Central Bank of Nigeria (CBN) statistical bulletins. The research made use of Ordinary least square (OLS) for its analysis. The findings show that there is a long run relationship between health expenditure and health outcome with Economic growth of Nigeria. From the analysis all the variables except secondary school enrollment conform to the economic a priori expectation. Health expenditure, gross capital formation and Life Expectancy  are positively related to economic growth in Nigeria while secondary school enrollment are negatively related to Economic growth in Nigeria within the period 1980 to 2015.The Study recommends that government should  invest  more in health  and ensure that the expenditure disbursed on health is properly utilized as it will bring about a good health outcome which will inevitably cause increased productivity that will tend to economic growth in Nigeria. Also it is recommended that Government should encourage savings and investment which is also necessary for economic growth; as well ensure a good universal education programme.